Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol.
نویسندگان
چکیده
An atom-economical purification protocol, using solution phase processing via ring-opening metathesis polymerization (ROMP) has been developed for the synthesis of tricyclic sultams. This chromatography-free method allows for convenient isolation of reductive-Heck products and reclamation of excess starting material via sequestration involving metathesis catalysts and a catalyst-armed Si-surface.
منابع مشابه
Phosphoramides, XIX [1] Phosphorus Pentoxide Amine Hydrochloride Reagents in the Synthesis of 3-Amino-l,2-benzisothiazole-l,l-dioxides and 3-Aminothieno [3,4-d] isothiazole-l,l-dioxides
3-Amino-l,2-benzisothiazole-1,1-dioxides (2b-n) have been prepared by heating saccharin (1) and the hydrochlorides of primary and secondary aliphatic amines with phosphorus pentoxide and N,N-dimethylcyclohexylamine at 240 °C. 3-Aminothieno[3,4-d]isothiazole-1,1-dioxides (6a-c) were similarly prepared from thieno[3,4-d]isothiazol3(2H)-one-1,1 -dioxide (5). 3 1 P NMR spectra were obtained of reac...
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 33 شماره
صفحات -
تاریخ انتشار 2011